Compound, its use, pharmaceutical composition, method for preventing, treating or ameliorating a disease against which a calcium antagonist is effective, method for suppressing neural brain death or protecting a brain neural cell, and method for preventing, treating or ameliorating neural disease. or pain

摘要

"COMPOSITION, ITS USE, PHARMACEUTICAL COMPOSITION, METHOD TO PREVENT, TREAT OR IMPROVE A DISEASE AGAINST WHICH A CALCIUM ANTAGONIST IS EFFECTIVE, A METHOD FOR SUPPRESSING NEURAL BRAIN DEATH OR PROTEINING THE CELL AND BRAIN PREMENAL CIRCLE NEURAL OR PAIN ". The present invention provides a novel compound having a higher calcium antagonism, in particular a selective neuron calcium antagonism. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate thereof. In the formula, Ar indicates an optionally substituted 5-14 membered aromatic ring, etc .; ring A denotes any ring selected from a piperazine, a homopiperazine, a piperidine and the like; ring B indicates an optionally substituted C 3-14 hydrocarbon ring etc .; E indicates a single bond, a group represented by the formula -CO-, etc .; X indicates a single bond, an oxygen atom, etc. ; R4 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc .; and D 1, R 2, W 2 and W 2 are the same or different from each other and each represents a single bond or an optionally substituted C 1-6 alkylene chain.