Compounds for impaired gastric fundus relaxation treatment

摘要

"COMPOSITIONS FOR HARMFUL RELAXATION TREATMENT OF THE GASTRIC BACKGROUND". The present invention relates to compounds of formula (I), a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -a ^ 1 ^ = a ^ 2 ^ -a ^ 3 ^ = a ^ 4 ^ - is a bivalent radical wherein one or two of a ^ 1 ^ aa ^ 4 ^ are nitrogen and the remainder of a ^ 1 ^ aa ^ 4 ^ are -CH =; -Z ^ 1 ^ -Z ^ 2 ^ - is a bivalent radical; A is a bivalent radical of the formula -N (R 6 6) - Alk 2 2 - and a 5-, 6- or 7-membered saturated heterocycle containing one or two nitrogen atoms; R 1, R 2 and R 3 are each independently selected from hydrogen, C 1-6 alkyl, hydroxy, halo and the like; Alk4-1 and Alk2-2 are optionally substituted C1-6 alkanediyl; R 5 is a radical of formula (d-1), (d-2), (d-3), (d-4), (d-5) wherein n is 1 or 2; p ^ 1 ^ is 0 and p ^ 2 ^ is 1 or 2, or p ^ 1 ^ i 1 or p ^ 2 ^ is 0; X is oxygen, sulfur or = NR 9 9; Y ^ 2 ^ is oxygen or sulfur; R 7 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, phenyl or phenylmethyl; R 18 is C 1-6 alkyl, C 3-6 cycloalkyl, phenyl or phenylmethyl; R 9 is cyano, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxycarbonyl or aminocarbonyl; R 10 is hydrogen or C 1-6 alkyl; and Q is a bivalent radical. Processes for preparing the products, formulations comprising these products and their use as a medicament are described, in particular for treating conditions that are related to disturbed accommodation of the gastric fundus.