A compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, use of a compound or salt, packaging and methods for, to alter the signal transducing activity of gaba receptors, to treat anxiety, depression, a sleep disorder, or dementia. alzheimer, to demonstrate the presence of gabaa receptors in cells or tissue samples and to prepare a compound

摘要

"COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND OR SALT, PACKAGING AND METHODS TO, TO ALTER THE SIGNAL TRANSDUCTIVE ACTIVITY OF GABA ~ A ~ RECEPTORS, TO DEVELOP ANXIETY, DEPRESSION, DISTANCE OR DEMONCIATION OF ALZHEIMER TO DEMONSTRATE THE PRESENCE OF GABA ~ A RECEIVERS IN FABRIC CELLS OR SAMPLES AND TO PREPARE A COMPOUND ". Compounds of Formula (I) and their pharmaceutically acceptable salts are disclosed wherein the variables R 1, R 2, R 3, n and Ar are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABA-A ~ brain receptors or prodrugs of GABA-A ~ brain receptors agonists, antagonists or inverse agonists and are therefore useful in the diagnosis and treatment. anxiety, depression, Down Syndrome, sleep and attack disorders, benzodiazepine drug overdose and memory enhancement.