1-Methylcarbapenem compound or a pharmaceutically acceptable salt or ester derivative thereof, pharmaceutical composition, and use of a compound or a pharmaceutically acceptable salt or ester derivative thereof

摘要

"1-Methylcarbapenem Compound or a Salt or Ester Derivative of This Pharmaceutically Acceptable, Pharmaceutical Composition, and Use of a Compound or Salt or Ester Derivative of This Pharmaceutically Acceptable". The present invention relates to 1-methylcarbapenem compounds having excellent antibacterial activity, their pharmaceutically acceptable ester derivatives, their pharmaceutically acceptable salts to pharmaceutical compositions (particularly antibacterial agents) containing them as active ingredient, to the use of the compounds, derivatives thereof. of ester or salts thereof to prepare such pharmaceutical compositions and to a method of preventing or treating diseases (particularly bacterial infections) wherein a pharmacologically effective amount of the compound, ester or salt derivative is administered to a warm-blooded animal (particularly a human being). human). The 1-methylcarbapenem compounds of the present invention are represented by the general formula (I): R1 is a group represented by the formula COOR3 (where R3 represents a hydrogen atom, a C1-4 alkyl group). 1 ~ -C ~ 6 ~ or the like), a group represented by the formula CONR ^ 4 ^ R ^ 5 ^ (wherein R ^ 4 ^ and R ^ 5 ^ each independently represents a hydrogen atom, a C 1-4 alkyl group). Which may be substituted or the like), a cyano group, a group represented by the formula CH 2 (OR R 6 6) (wherein R 6 is a hydrogen atom, an alkyl group C ~ 1 ~ -C ~ 6 ~ or the like) or a group represented by the formula CH ~ 2 ~ NR ^ 7 ^ R ^ 8 ^ (where R ^ 7 ^ represents a hydrogen atom, a C ~ 1 alkyl group ~ -C ~ 6 ~ or the like and R ^ 8 ^ represents a hydrogen atom, a C 1-1 alkyl group, a C 1-6 alkanoyl group, a C 1-6 alkoxy group ~ 1 ~ -C ~ 6 ~ carbonyl or the like); R 2 represents a hydrogen atom or a C 1 -C 6 alkyl group; n represents 1, 2 or 3; and X represents a sulfur atom or an oxygen atom.