Method for Preparation of 2 - 5 - (4-fluorophenyl) - 3 - piridilmetilaminometil chromane; useful as Selective dopamine D2 Receptor Antagonists and agonist for the 5-ht1a receptor.

摘要

The present Invention relates to a process for the preparation of 2 - (5 - 4fluorophenyl) - 3 - piridilmetilaminometil chromane, enetiomeros) and its SaltsWherein is reacted directly 5 - (4-fluorophenyl) pyridin - 3 - carbaldehido with aminometilcromano or its Salts in Reductive conditions to obtain the2 - (5 - (4-fluorophenyl) - 3 - piridilmetillaminometil) chromane, and if desired,The latter becomes one of its Salts acceptable physiologically by Treatment with acid.