Monoclonal antibody anti Human FAS, hfeza, Pharmaceutical composition containing itUseful for treating or Preventing Bone Wear caused by a disease that activates osteoclasts and Selection method of bone Drugs against wear.

摘要

It provides a Pharmaceutical composition for the Treatment or prevention of bone erosion caused by disease (e.g., active osteoclastsRheumatoid arthritis) that includes a hfe7a FAS monoclonal antibody anti human or Humanized version of it; it also provides a method for Testing a substance for the TreatmentTo Wear or prevention of bone transplanting is: parts of Dentin and synovial tissue of a patient suffering from a disease which activates osteoclasts in non-human mammalsMunodeficientes; Administering the substance to be tested to at least one of the test animals and at least one control animal of different Test and raise them; and then remove the FootZas Dentin of the test animals and count the number of resorption cavities formed in the superficei each piece that was in contact with the sample of synovial tissue.