Antagonists of the release factor corticitropina and related compositions

摘要

1. The use of corticosteroid releasing factor cubes in the manufacture of drugs for the treatment or prevention of syndrome X includes the provision of a certain number of cubes from corticosteroid releasing factors to the animal. 1. Use requirement 1 to effectively manage the release of factor from corticosteroids. 1. Using claim 2, in which the opposite cube of the cortisol release factor is a formula EMI file = "00080519" U1 "id =" 1 "IMF = JPEG and the addition of salt to the acid acceptable for the drug,A is nr1r2, cr1r2r11 or C (= cr1r12) R2, nhcr1r2r11, kr1r2r11, nnnr1r2, cr2r11nhr1, cr2r11or1, cr2r11sr1 or C (or) r2.r1 is hydrogen or C1-C6 tar, which can be replaced by one or two R6 independently selected from the hydrogen Xi, fluorine, carbon chloride, carbon chloride and C16 groups, O-C (o) - (C1-C6 tar),O-C (o) - n (C1-C4 asphalt) (C1-C2 asphalt)Amino, NH (C1-C4 tar),S (C1-C6 asphalt)OC (o) NH (C1-C4 tar),N (C1-C2 alkyl) C (O) (C1-C4 alkyl),NHC (o) (C1-C4 tar)COOH, CO (C1-C4 tar)C (o) NH (C1-C4 tar),C (o) n (C1-C4 tar) (C1-C2 tar),SH, CN, no, so (C1-C4 tar)SO2 (C1-C4 tar) so2nh (C1-C4 tar),2. There may be a double or triple link between so2n (C1-C4 tar) (C1-C2 tar) and C1-C6 tar. Benzomihizolilo, trialilo, Lilo, lilio, lilio, Indolilo, azindolilo, oxazolilo, oxazolilo, cycloquilo de 3-8 member o (burealen C1-C6) cycloquilo, and there may be 1-2o, s or N-Z, which is Z hydrogen,Replace the cyclopentanediol, C1-C4, C1-C4, benzene or alkane with one or two kinds of carbon independently,