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Use of a chemical mutant for the preparation of pharmaceutical compositions for the treatment of multiple sclerosis and other myelitis-related diseases
Use of a chemical mutant for the preparation of pharmaceutical compositions for the treatment of multiple sclerosis and other myelitis-related diseases
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机译:化学突变体在制备用于治疗多发性硬化症和其他脊髓炎相关疾病的药物组合物中的用途
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摘要
Mutants of CC chemokines, which contain at least two mutations in the cationic site of the 40's loop and which, relative to the wild-type molecule, have a reduced GAG-binding activity. In particular it has been found that such mutated chemokines are effective in the treatment of multiple sclerosis and/or demyelinating diseases. A triple mutant of RANTES is the compound showing the best results.
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