5-oxo-7H-pyrido 2,1-b 1,3 thiazepine, 4-oxo-2H, 6H-pyrido 2,1-b 1,3 thiazine and 5-oxo- 2,1-b 1,3 tiazepinderivat

摘要

Compounds of the formula CHEM wherein X is O or S-(O)t; n is one or two; m is zero or one; Y is CH2, O, or S-(O)t provided that Y is O or S-(O)t only when m is one; and A is CHEM are dual inhibitors of NEP and ACE. Compounds wherein A is CHEM are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.