OX(ADI)AZOLYL-HYDROXAMIC ACIDS USEFUL AS PROCOLLAGEN C-PROTEINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

SUMMARY OF THE INVENTION The present invention relates to pharmaceutically acceptable salts and solvates of the compounds of formula (I), including hydrates thereof, and their prodrugs, wherein X is an optionally substituted C 1-6 alkylene or C 2-6 alkenylene, R is optionally substituted aryl or 3 -8 carbon atoms cycloalkyl, W is N or CZ, Y and Z are independently H, optionally substituted 1-4 carbon atoms, C 1-4 alkanoyl, C 1-4 alkoxycarbonyl, or CONR 1 R 2, R 1 and R 2 independently of one another two or two further heteroatoms selected from N, O, independently selected from H, C 3-8 cycloalkyl, optionally substituted C 1-4 alkyl, or R 1 and R 2 together with the nitrogen to which they are attached. and S atoms, which is a heterocyclic ring optionally having a benzo or pyrido group condensed or optionally substituted, R3 and R4 independently of one another are H, or optionally substituted 1-4 carbon atoms, or C1-4alkoxycarbonyl, or R3 and R4 taken together with the nitrogen atom to which they are attached form a single-morpholine, piperidine, azetidine- or piperazine ring optionally substituted with C 1-4 alkyl, R 5 is optionally substituted 1-4 carbon atoms, or may be aryl, R 6 is optionally substituted C 1-4 alkyl, or aryl, R 7 is H or R6, p is 0.1 or 2. The compounds of the invention have procollagen C proteinase (PCP) inhibitory activity. The invention also relates to the preparation of compounds and pharmaceutical compositions containing them. HE