A METHOD AND KIT FOR ENHANCING OLIGONUCLEOTIDE-MEDIATED GENE ALTERATION

摘要

Methods are presented for enhancing the efficiency of oligonucleotide-mediated repair or alteration of genetic information. The methods comprise using cells or cell-free extracts having altered levels or activity of at least one protein from the RAD52 epistasis group, the mismatch repair group or the nucleotide excision repair group. Kits and compositions are also presented.