METHODS, COMPOSITIONS, AND KITS FOR ENHANCING OLIGONUCLEOTIDE-MEDIATED NUCLEIC ACID SEQUENCE ALTERATION USING COMPOSITIONS COMPRISING A HISTONE DEACETYLASE INHIBITOR, LAMBDA PHAGE BETA PROTEIN, OR HYDROXYUREA

摘要

The invention is directed to oligonucleotide-mediated repair or alteration of genetic information, such as nucleic acid sequence alteration, and methods, compositions and kits for enhancing the efficiency of such alteration. Specifically, the invention incorporates the use of factors such as Histone Deacetylase Inhibitor (HDAC), Lambda phage beta protein, or hydroxyurea to achieve such enhanced efficiency.