METHODS FOR SELECTIVELY MODULATING SURVIVIN APOPTOSIS PATHWAYS.

摘要

The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34cdc2 cyclin B1 kinase complex, and the interaction between survivin and caspase 9. Related methods and compositions can be used to modulate survivin regulated apoptosis.