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PHARMACEUTICAL COMPOSITIONS COMPRISING A DIFFICULTLY SOLUBLE ACTIVE AGENT, A HYDROPHILIC PHASE, A LIPOPHILIC PHASE AND A SURFACTANT
PHARMACEUTICAL COMPOSITIONS COMPRISING A DIFFICULTLY SOLUBLE ACTIVE AGENT, A HYDROPHILIC PHASE, A LIPOPHILIC PHASE AND A SURFACTANT
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机译:药物组合物,其包含难溶的活性剂,亲水相,脂相和表面活性剂
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摘要
This invention provides a microemulsion pre-concentrate comprising a difficultly soluble agent and a carrier medium comprising: 1) a hydrophilic phase which comprises dimethyisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporine or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.
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