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Kinazolinderivater, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmåte for fremstilling derav

机译:喹唑啉衍生物,含有这些化合物的药物,其用途和制备方法

摘要

The invention relates to quinazoline derivatives of general formula (I), wherein Ra, Rb and Rc have the meaning defined in claim 1, to their tautomers, their stereoisomers and their salts, especially their physiologically acceptable salts with inorganic or organic acids. Said compounds have valuable pharmacological properties, especially an inhibiting effect upon signal transduction caused by tyrosine kinase. The invention further relates to their utilization in the treatment of diseases, especially of tumoral diseases, diseases of the lung and the respiratory tract and to the production of said compounds.
机译:本发明涉及通式(I)的喹唑啉衍生物,其中Ra,Rb和Rc具有权利要求1中定义的含义,包括其互变异构体,其立体异构体及其盐,尤其是它们与无机或有机酸的生理学可接受的盐。所述化合物具有有价值的药理性质,特别是对酪氨酸激酶引起的信号转导的抑制作用。本发明进一步涉及它们在疾病尤其是肿瘤疾病,肺和呼吸道疾病的治疗中的用途以及所述化合物的生产。

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