5-leddete heterocykler, fremstilling og anvendelse derav som MAO inhibitorer og lipidperoksidasjonsinhibitorer, fremstilling derav oganvendelse derav sommedikamenter

摘要

The invention relates to derivatives of thiazoles, oxazoles or imidazoles having at least one of the following pharmacological activities: inhibition of monoamine oxidases (MAO's); inhibition of lipidic peroxidation; modulation of sodium channels. These compounds include for example: 2,6-ditert-butyl-4-{2-[2-(methylamino)ethyl]-1,3-thiazol-4-yl}phenol; and 4-methylpentyl 2-[4-(1,1'-biphenyl-4-yl)-1H-imidazol-2-yl]ethylcarbamate. As a result of their pharmacological properties, said compounds can in particular be used to treat one of the following disorders or diseases: Parkinson's disease, senile dementia, Aizheimer's disease, Huntington's chorea, amyotrophic lateral sclerosis, schizophrenia, depressions, psychoses, migraine or pains and in particular neuropathic pains.