Processes for producing 7-isoindolinequinolonecarboxylic derivatives and its intermediates, as well as salts of 7-isoindolinequinolonecarboxylic acid derivatives, its hydrates and composition comprising the same as active ingredient

摘要

Processes for producing an antibacterial agent 7-isoindoline-quinolonecarboxylic acid derivative of formula (1), wherein either: (i) Isoindoline-5-boronic acid derivative of formula (2) is reacted with metallic palladium; (ii) 5-halogenoisoindoline derivative of formula (4) is reacted with metallic palladium catalyst.