Compositions and methods for enhancement of major histocompatibility complex class 1 restricted antigen presentation by attaching the antigen to a specific peptide

摘要

Compositions and methods for eliciting an in vivo cytotoxic lymphocyte (CTL) response against a modified soluble protein antigen are disclosed. The modified soluble protein antigen comprises an added peptide sequence that facilitates entry of the modified antigen into antigen presenting cells (APC). Such compositions and methods are useful for promoting an immune response to a the antigen, and in particular for treating cancer.