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Naftiridin derivatives as inhibitors of cyclic nucleotide phosphodiesterase isoenzyme
Naftiridin derivatives as inhibitors of cyclic nucleotide phosphodiesterase isoenzyme
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机译:Naftiridin衍生物作为环核苷酸磷酸二酯酶同工酶的抑制剂
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摘要
Naftiridin relates to compounds of formula I wherein R1 is a monovalent Aromatic Group; R2 is a Group ciocloalifatico.Preferred compounds are etilester acid, 4 - [2 - (3 - cyano - phenyl) - 6 - [1,7] naftiridin - yl] - ciclohexancarboxilico acid; 4 - [8 - (3 - cyano - phenyl) - [1,7] - naftiridin] - ciclohexancarboxilico IL - 6 - 4 - acid potassium sa [8 - (3 - cyano - phenyl) - 2 - [6 - naftiridin - yl] - ciclohexancarboxilico acid, 4 - [2 - (3 - carbamoyl - F Enil) - 6 - [1,7] naftiridin - yl] - ciclohexancarboxilico, among others.It also relates to a process for Preparation. The compounds are inhibitors of cyclic nucleotide phosphodiesterase isoenzyme or inhibit the release of NPT - and may be useful for their anti-inflammatory, anti Airway hyperactivity and bronchodilator
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