2-Thioindoles, 2-indolinethiones and polysulfides, their analogues (2-indolineselenone) (selenide), and pharmaceutical compositions based on them

摘要

2-Thioindoles, 2-indolinethiones and polysulfides, their selen analogues of formula (A), wherein one or two groups -CH= of benzene ring in the formula (A) can be replaced by -N=; R1 is C-bounded substituent selected from the group comprising H, halogen, R, OH, OCOR, OR, CF3, NO2, NH2, NHR, COOH, CONHR, (CH2)nOH, (CH2)nOR, (CH2)nNH2, (CH2)nNHR or (CH2)nNRR; R2 is alkyl with 2 to 4 C or (CH2)nCOOH, (CH2)nCOOR, (CH2)nCOR, (CH2)nSO2R, (CH2)nSO2NRR, (CH2)nSO2NHR, CH=CHCOOH, (CH2)nCH(OH)COOH, (CH2)nCH(NH2)COOH, (CH2)nCONH2, (CH2)nCONHR, (CH2)nCONRR, (CH2)nCONHCH2Ph, CONHR, CONRR, CONHPh, COY, COPhCOOH, COPhCOOR, (CH2)nCONHPh, (CH2)nCONHPhR or SO2Y; n is integral number 1 to 4; R is alkyl with 1 to 4 C; R3 is H, alkyl with 1 to 4 C or benzyl; Y is cyclic residual derived from benzene, pyridine, thiophene, furane, thiazole or imidazole, which is optionally substituted by alkyl with 1 to 4 C or COOH, OH, OCOR, NH2, CONHR, CONRR, OR or NHR; R4 is S, SH, SOX or SOQ, wherein o is an integral number 1, 2 or 3 and X is H, alkyl with 1 to 4 C, benzyl or cyclic residual derived from benzene, pyridine, thiophene, furane, thiazole or imidazole and Q is another 2-thioindole residual of general formula (A); or R4 is Se, SeH, SeOX or SeOQ, wherein o is a number with the value 1, 2 or 3 and X is H, alkyl with 1 to 4 atoms C, benzyl or cyclic residual derived from benzene, pyridine, thiophene, furane, thiazole or imidazole and Q is another 2-selenoindole residual of general formula (A); and dashed lines represent additive bonds, from which is present always only one, whist the occurred double bond is endocyclic, if the residual R4 is univalent and exocyclic, if the residual R4 is bivalent; and their pharmaceutically acceptable salts, which are protein tyrosine kinases inhibitors; pharmaceutical compositions based on them.