Biciclicas pyrimidines as inhibitors of Matrix Metalloproteinases ref.pca425-01 700029 / BB /

摘要

Are Selective inhibitors of MMP - 13 biciclicas pyrimidines of formula I or a pharmaceutically acceptable Salt thereof, wherein R1 is Hydrogen or alkyl; R2R3 and R4 include Hydrogen, alkyl, Halo, _ c = C (CH2) M CO2 CO2 aryl, alkyl, aryl, (CH2) m, Cohn (CH2) m with alkyl and aryl; and X is o, S, so, SO2, CH2, c = o, NH, or Choh, NR5.A compound of formula I or a pharmaceutically acceptable Salt thereof is useful for treating cancer or arthritis.