SOLID COMPOSITION CONTAINING SOLID FIBRINOGEN AND SOLID THROMBIN WHICH IS USEFUL FOR TISSUE GLUING, TISSUE SEALING AND BLEEDING ARREST, METHOD FOR GLUING AND SEALING TISSUES, METHOD FOR BLEEDING ARREST

摘要

The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm3, chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glycolic acid, hydroxybutanoic acid, a cellulose, gelatin or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type 1 fibres. The fibrinogen and thrombin are preferably human, purified form a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibrinolytic agent such as aprotinin, -aminocaproic acid or -antiplasmin.