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Use of cyclohexane polycarboxylic acids as plasticizers in the production of plastics which are rated toxicologically favourable.
Use of cyclohexane polycarboxylic acids as plasticizers in the production of plastics which are rated toxicologically favourable.
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机译:环己烷多元羧酸在塑料生产中的用途,该塑料在毒理学上被认为是有利的。
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摘要
The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.
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