PHARMACEUTICAL COMPOSITIONS WITH CONTROLLED RELEASE FOR ORAL ADMINISTRATION CONTAINING NIFEDIPINE AS AN ACTIVE SUBSTANCE

摘要

Controlled release pharmaceutical compositions for the oral administration of nifedipine comprising an amorphous coprecipitate of nifedipine and polyvinylpyrrolidone and suitable excipients, the release being modulable from 8 to 24 hours modifying the amount and the kind of used excipients. Said compositions show a high solubility and bioavailability in addition to the advantage of the controlled release.