PROCEDURE OF PRODUCTION OF ACTIVATED T CELLS MARKED SPECIFIC TUMORS AND ITS USE FOR TUMOR TREATMENT.

摘要

A PROCEDURE IS DESCRIBED FOR THE PRODUCTION OF ACTIVATED T CELLS, TUMOR SPECIFICATIONS, BY CO - CULTURE, EX VIVO, OF TUMOR CELLS OF A PATIENT T-CELLS, AND THAT INCLUDES THE STAGES OF: I) INCLUDING THE CELLS WITH A FIRST FUSION PROTEIN OBTAINED FROM A B7 PROTEIN AND AN ELEMENT OF A BIOLOGICAL FIXING PAIR, AND A SECOND FUSION PROTEIN OBTAINED FROM AN ANTIBODY AGAINST AN ANTIGEN OF THE CELL SURFACE AND ANOTHER ELEMENT OF THE BIOLOGICAL COUPLE FIXATION; II) INHIBIT THE PROLIFERATION OF TUMOR CELLS BEFORE OR AFTER SUCH INCUBATION; III) CO - CULTIVATE TUMOR CELLS WITH T-CELLS TO BE ACTIVATED, UNTIL THE ACTIVATION OF T-CELLS IS ACHIEVED; IV) SEPARATE THE ACTIVATED T CELLS FROM THE TUMOR CELLS, PROCEDURE THAT IS FULLY EFFICIENT AND CAN BE DEVELOPED SIMPLY.