ANALOGS OF 20 (S) -CAMPTOTECINA IN RING C SOLUBLES IN WATER.

摘要

NEW TOTECINE RING HYDROSOLUBLE ANALOGS, OF GENERAL FORMULA (1). ALL FORMULA COMPOUNDS (1) ARE PREPARED FROM THE GENERAL FORMULA COMPOUNDS (2), WHICH HAVE A CHIRAL CARBON 20 (S), WHERE R SUP, 1} A R SUP, 5} HAVE THE MEANING EXPRESSED ABOVE. THE FORMULA COMPOUNDS (1) HAVE POWERFUL ANTI-BANK AND ANTI-VIRECT PROPERTIES. THE INVENTION ALSO PROVIDES AN ALTERNATIVE PROCEDURE FOR THE PREPARATION OF KNOWN COMPOUNDS, SUBSTITUTED IN C