Treating surface of implant or prosthesis, useful e.g. as hip or knee replacement, by sequential contact with three mineral acids to produce rough texture

摘要

Method for treating the surface of implants or prostheses (A) made of titanium or other material and having a smooth surface on the upper part and the threaded attachment, and a rough surface on the rest of the threaded portion as far as (and optionally including) the apical extremity. The roughness is created by successive, and separate, treatments with: (i) 5% hydrofluoric acid for about 30 sec; (ii) 97% sulfuric acid for 3 min at 70 degreesC and (iii) 36.5% hydrochloric acid for 3-5 min at 70 degreesC. After (iii), (A) is neutralized with sodium carbonate for 5-30 sec, with stirring, followed by washing with deionized water, optionally with application of ultrasound. The roughened part of (A) is then covered with a surface layer of plasma, rich in growth factors, derived from the patients own blood.