Combination product combining a nucleic acid to a substance that disrupts the extracellular matrix for gene therapy.

摘要

The present invention relates to a combination product comprising at least one substance which leads to disorganization of the extracellular matrix of a cell and at least one nucleic acid of interest, for simultaneous, consecutive or extended administration time, said nucleic acid carried by an infectious viral particle or as a synthetic vector. The invention also relates to their use for therapeutic or vaccine purposes for the preparation of a medicament for the treatment of the human or animal body by gene therapy and the use of a substance which leads to disorganization of the extracellular matrix to enhance the transfer and / or expression of the nucleic acid of interest mentioned above in a cell or a host organism.