SHARK CARTILAGO EXTRACTS, WHICH HAVE AN ANTI-ANGIOGENIC ACTIVITY AND EFFECT IN TUMOR REGRESSION, PROCESS FOR THEIR PRODUCTION.

摘要

THE PRESENT INVENTION REFERS TO EXTRACTS OF CARTILAGO DE TIBURON AND TO A METHOD FOR PRODUCING THESE EXTRACTS. THEY HAVE ANTIANGIOGENIC PROPERTIES (THE REDUCTION OF THE AREA OF BLOOD VESSELS HAS BEEN LIVED IN VIVID IMMEDIATELY ASSOCIATED TUMORS) A DIRECT INHIBITORY EFFECT ON THE TUMOR CELL LINES. THIS PROCESS DOES NOT NEED ANY PRODUCT OR DENATURALIZING SOLVENT OR THE USE OF ANY ENZYMES. IT CONSISTS IN OBTAINING A MIXTURE OF THE CARTILAGO ASSEMBLY IN A WATERPROOF SOLUTION OF NEUTRAL PH, PREFERIBLY PURE WATER, THIS MIXTURE IS CENTRIFUGATED BUTTING THE BOLITA AND THE SUPERIOR FOR A POST PROCESSING. THE BOLITA IS LIOPHILIZED AND TESTED IN ANTI-VARIOUS AND ANTIANGIOGEN ACTIVITIES IN VIVO AND IN VITRO, WITH OR WITHOUT OVERLINING. THE SUPERIOR HAS DEMONSTRATED TO HAVE IN VIVO ANGIOGENIC AND TUMOR REGRESSION ACTIVITY. THE COMPOSITION OF THE SUPERNERSHIP HAS BEEN INVESTIGATED IN DIFFERENT FORMS. THE FRACTIONATION OF THIS SUPERIOR ALLOWS THE CHARACTERIZATION OF SOME OF ITS ACTIVE COMPONENTS. THE LIVE DIRECT ACTIVITY OF THE FRACTIONS HAS BEEN TESTED ON THE TUMOR CELL LINES. IN ADDITION, IT IS ASSUMED THAT THE NON-FRACTIONED ENVELOPE HAS THE SAME ACTIVITY IN VITRO. LIOFILIZATION SUSTAINABLY DESTROYS THE ACTIVITY OF THESE LIQUID FRACTIONS WITHOUT THIS DESTRUCTION IN THE SOLID EXTRACT.