Use of hyaluronic acid derivatives with ridimensionales structures enclosing cavities created by pores communicated and / or fine fibers or microfibres entangled, for the preparation of biocompatible biomaterials for in vivo regeneration of tissue cells.

摘要

Use of at least one derivative selected from the group consisting hyaluronic acid: A) Esters of hyaluronic acid wherein part or all of the functions of carboxy are esterified with alcohols of the aliphatic, aromatic series, arylaliphatic, cycloaliphatic and heterocyclic; B) Esters with self-cross linking hyaluronic acid in which all or part of the carboxy groups are esterified with the alcoholic functions of the same polysaccharide chain or other chains; C) cross hyaluronic acid wherein part or all of the carboxy groups are esterified with polyalcohols of the aliphatic, aromatic series, arylaliphatic, cycloaliphatic, heterocyclic series, generating cross-linking by means of spacer chains Esters; D) hemiesters of succinic acid or salts of heavy succinic acid hemiester with hyaluronic acid or with partial or total esters of hyaluronic acid metal; E) sulfated derivatives (WO 95/25751) or N-sulphated derivatives, said processing being hyaluronic acid derivative in the form of a three-dimensional structure enclosing cavities created by pores communicated and / or fine fibers or microfibres entangled, for making biomaterials biocompatible for in vivo regeneration of tissue cells, characterized in that: i) I said biocompatible biomaterial lacks cellular components or products thereof; ii) when the hyaluronic acid derivative belongs to class (A) indicated above and processed into a nonwoven fabric it has an esterification degree lower than 85%.