IMMUNOMODULATION METHOD THROUGH ADOPTIVE TRANSFER OF SPECIFIC ANTIGEN T-CYTOTOXY LYMPHOCYTES.

摘要

A METHOD FOR THE PRODUCTION OF CYTOTOXIC T-CELLS (CTLS) ANTIGEN SPECIFICATIONS THROUGH THE INCUBATION OF A PREPARATION THAT CONTAINS T-CELLS WITH SUCH ANTIGEN AND ISOLATED THOSE SPECIFIC CTLS OF ANTIGENS, WHICH IS CHARACTERIZED BECAUSE OF THE CT IN THE LAB CELL PREPARATION THROUGH AN INCUBATION WITH THE ANTIGEN; II) A VECTOR IS SELECTLY TRANSFERRED TO THE PROLIFERANT CTLS, WHERE THE VECTOR CONTAINS A MARKER GENE WITH WHICH THE MARKED AND UNMARKED CELLS CAN BE SEPARATED; AND III) THE SPECIFIC CTLS OF ANTIGENS TRANSFECTED ON THE BASIS OF THIS MARKER GENE, WHICH IS USEFUL FOR IMMUNOMODULATION, ARE SEPARATED.