GENES AND THEIR GENETIC PRODUCTS PERTINENT TO MICROSATELLITE INSTABLE (MSI+) TUMOURS

摘要

The invention relates to genes comprising coding mononucleotidemicrosatellites (cMNR) or dinucleotide microsatellites (cDNR). The genes canbe isolated from MSI+ tumour cells. Said genes differ from corresponding genesfrom non-MSI+ (tumour) cells by mutations in the cMNR or cDNR and code forgene products including neopeptides. The invention also relates to the use ofthe genes and their gene products for the prevention, diagnosis and/or therapyof MSI+ tumours.