DIAGNOSTIC METHODS FOR CARDIOVASCULAR DISEASE, LOW HDL-CHOLESTEROL LEVELS, AND HIGH TRIGLYCERIDE LEVELS

摘要

A method for determining propensity toward developing a cardiovascular diseasein a patient at risk thereof by determining the presence in an ABCA1 gene ofsaid patient of a polymorphism in the DNA sequence of the gene wherein saidpolymorphism is present in a non-coding region of said gene is disclosed. Alsodescribed is a method of identifying a modulator of ABCA1 polynucleotideexpression comprising by determining the ability of a test compound tomodulate the activity of a polynucleotide comprising a polymorphism disclosedherein, or to mimic the effects of such polymorphism where such effects arebeneficial. Treatment of cardiovascular disease, especially coronary arterydisease, using agents identified by the disclosed methods is also described.