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Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
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机译:心血管疾病,低密度脂蛋白胆固醇水平和高甘油三酸酯水平的诊断方法
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摘要
A method for determining propensity toward developing a cardiovascular disease in a patient at risk thereof by determining the presence in an ABCA1 gene of said patient of a polymorphism in the DNA sequence of the gene wherein said polymorphism is present in a non-coding region of said gene is disclosed. Also described is a method of identifying a modulator of ABCA1 polynucleotide expression comprising by determining the ability of a test compound to modulate the activity of a polynucleotide comprising a polymorphism disclosed herein, or to mimic the effects of such polymorphism where such effects are beneficial. Treatment of cardiovascular disease, especially coronary artery disease, using agents identified by the disclosed methods is also described.
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