METHODS FOR TREATMENT OF CANCER USING IRINOTECAN BASED ON UGT1A1

摘要

The present invention relates to the use of irinotecan or a derivative thereoffor the preparation of a pharmaceutical composition for treating colorectalcancer, cervical cancer, gastric cancer, lung cancer, malignant glioma,ovarian cancer, and pancreatic cancer in a patient having a genotype with avarient allele which comprises a polynucleotide in accordance with the presentinvention. Preferably, a nucleotide deletion, addition and/or substitutioncomprised by said polynucleotide results in a altered expression of a variantallele compared to the corresponding wild type allele or an altered activityof the polypeptide encoded by the variant allele compared to the polypeptideencoded by the corresponding wild type allele. Finally, the present inventionrelates to a method for selecting a suitable therapy for a subject sufferingfrom colorectal cancer, cervical cancer, gastric cancer, lung cancer,malignant glioma, ovarian cancer, and pancreatic cancer.