MYCOPLASMA BOVIS CHALLENGE MODEL, METHODS FOR ADMINISTERING M.BOVIS AND METHODS FOR INDUCING PNEUMONIC LUNG LESIONS

摘要

The present invention provides a reproducible M. bovis challenge model andmethods for reliably inducing and establishing a disease or disorder caused byinfection with M. bovis by administering to an animal an effective amount of aM. bovis culture. The challenge culture of the present invention isadministered in an amount sufficient to elicit M. bovis specific cellular orhumoral immune responses. The M. bovis challenge model in accordance with thepresent invention can be used to evaluate the efficacy of potential vaccines.