2-PHENYL BENZIMIDAZOLES AND IMIDAZO-4,5-PYRIDINES AS CDSI/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER

摘要

2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines of formula (I) a re disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. wherein W is COOH, -(CO)NHR1, or -(SO2)NHR1 R1 is H or C1-4alkyl; Q is N or CH; Ra and Rb are H or halogen; Y , Y1 and Y2 are independently selected from N and C-Rc with the proviso that 0 , 1 or 2 of Y, Y1 and Y2 are N and at least 2 of Rc must be hydrogen; Rc are independently selected from the group consiting of -H, -OH, -C1-6alkyl, -SCF 3, halo, -CF3 and -OCF3; Z is selected from the group consisting of O, S, SO, SO2, SO2NR2, NR2SO2, NH, CONR2, piperazin-diyl or a covalent bond; R2 is H o r C1-4alkyl; AR1 is an aromatic group as defined in the claims.