SUSTAINED RELEASE FILM PREPARATION FOR LOCAL ADMINISTRATION COMPRISING PROSTAGLANDIN DERIVATIVE AS ACTIVE INGREDIENT

摘要

A persistent filmy preparation which comprises methyl(11.alpha.,13E,15.alpha.)-9-oxo-11,15-dihydroxy-16-(3-methoxymethylphenyl)-17,18,19,20-tetranor-5-thiaprost-13-enoate represented by the formula (I): (I)or a nontoxic salt thereof as an active ingredient and a bioabsorbable polymeras a substrate and which is for use in topical administration to a sicklocation where the bone amount is small; and a remedy for bone amountreduction which comprises the persistent filmy preparation. The persistentfilmy preparation, which contains the compound (I) as an active ingredient,promotes bone formation upon topical administration and is useful fortreatments for bone amount reduction.