Method and pharmaceutical composition for inducing cancer cell-specific apoptosis by combination with tnf family proteins and flavopiridol

摘要

PURPOSE: A cancer cell specific apoptosis-inducing composition using the combination of tumor necrosis factor(TNF) proteins and flavopiridol is provided, thereby toxicity and side-effects by using high concentration of the individual substance can be decreased, and apoptosis can be improved. CONSTITUTION: The cancer cell specific apoptosis-inducing composition comprises the combination of tumor necrosis factor(TNF) proteins and flavopiridol, wherein the TNF protein is any one selected from the group consisting of TNF-α, TNF-related apoptosis-inducing ligand(TRAIL) or their N-terminal or C-terminal containing protein mutants; the amount of the TNF proteins contained is 1.0 to 2000μg/ml; and the amount of the flavopiridol contained is 1.0 to 1000μg/ml.