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CALPAIN LARGE SUBUNIT (n-CL4) CYSTEINE PROTEASE GENE DISRUPTIONS, AND COMPOSITIONS AND METHODS RELATED THERETO
CALPAIN LARGE SUBUNIT (n-CL4) CYSTEINE PROTEASE GENE DISRUPTIONS, AND COMPOSITIONS AND METHODS RELATED THERETO
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机译:钙蛋白大亚基(n-CL4)半胱氨酸蛋白酶基因突变及其组成和方法
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摘要
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an n-CL4 cysteine protease gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
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