METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER

摘要

The present invention provides means to modulate gene expression by destabilizing or stabilizing mRNA species. The invention provides compositions and methods for altering the level of RNA, and for screening test agents that alter RNA levels. The inventions's compositions and methods are useful in, for example, increasing the level of an mRNA and conversely in decreasing the level of mRNA by impacting the level of degradation of the mRNA.