METHOD FOR ENHANCING IMMUNE RESPONSES BY CODELIVERING INFLUENZA NP DNA IN DNA IMMUNIZATION

摘要

The present invention relates to the use of influenza NP (nucleoprotein) DNA as an adjuvant for enhancing immune responses to a DNA vaccine, in particular, a method for enhancing immune responses by codelivering influenza NP DNA and DNA vaccine against an immune antigen, and a vaccine composition comprising said influenza NP DNA and said DNA vaccine for the immune antigen. According to the method of the present invention, the influenza NP gene DNA is used as an adjuvant for a DNA vaccine to enhance the immune response of the DNA vaccine such that it can be used for effective prevention against or treatment of influenza, AIDS, hepatitis B, hepatitis C, cancer, tuberculosis, malaria, etc. and to assist in the development of influenza vaccines.