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USE OF RECOMBINANT HEPATITIS B CORE PARTICLES TO DEVELOP VACCINES AGAINST INFECTIOUS PATHOGENS AND MALIGNANCIES
USE OF RECOMBINANT HEPATITIS B CORE PARTICLES TO DEVELOP VACCINES AGAINST INFECTIOUS PATHOGENS AND MALIGNANCIES
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机译:使用重组乙型肝炎核心颗粒形成针对感染性病原菌和疟疾的疫苗
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摘要
The present invention relates to methods and compositions for augmenting CD8+ T cell responses to an antigen in a mammal, comprising the use of recombinant hepatitis B core particles (rHEP) to present said antigen. The invention further relates to a method of boosting the rHEP particle-induced CD8+ T cell responses using secondary immunization with a recombinant vaccinia virus expressing the same antigen (rVAC). The methods and compositions of the present invention can be useful for prophylaxis and treatment of various infectious and neoplastic diseases.
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