Novel thrombomodulin expression promoters

摘要

It is intended to provide a novel pharmaceutical effect of HMG-CoA reductase inhibitors, in particular, (+)-(3R, 5S, 6E)-7-Ä2-cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜ-3,5-di hydroxy-6-heptenoic acid or its salt. Namely, TM expression promoters, more specifically speaking, antithrombotic drugs, preventive/remedies for sepsis, antiplatelet drugs and anticoagulants comprising as the active ingredient an HMG-CoA reductase inhibitor, in particular, (+)-(3R, 5S, 6E)-7-Ä2-cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜ-3,5-dihydroxy-6 - heptenoic acid or its salt.