USE OF DEATH RECEPTOR LIGANDS OR RIP TO INITIATE THE NON-CASPASE-DEPENDENT CELL DEATH AND COMPOUNDS FOR INHIBITION OF THE NON-CASPASE-DEPENDENT CELL DEATH

摘要

The invention relates to the use of physiologically occurring protein, in particular of death receptor ligands or RIP, to initiate the non-caspase-dependent cell death in immune system cells. The invention further relates to compounds, in particular also antibodies, which inhibit the initiation of the non-caspase-dependent cell death, with particular activity in inhibiting the signal transmission path by means of the protein RIP. The invention also relates to a method for identification of the above compounds.