COMPOSITIONS AND METHODS FOR AFFECTING VIRULENCE DETERMINANTS IN BACTERIA

摘要

A novel sar R gene and sar R gene product which down regulates the expression of sar A and the resulting virulence determination in Staphylococcus aureus is provided. Methods for modulating the expression of sar A and virulence determinants are also provided. A preferred embodiment of the present invention provides structural information relating to the gene product and enables the identification and formulation of lead compounds and reducements for treating and preventing infections by S. aureus and related bacteria.