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Compositions and methods for affecting virulence determinants in bacteria

机译：影响细菌中毒力决定因素的组合物和方法

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摘要

A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants in Staphylococcus aureus is provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A preferred embodiment of the present invention provides structural information relating to the gene product and enables the identification and formulation of lead compounds and reducements for treating and preventing infections by S. aureus and related bacteria.

机译：提供了一种新的sarR基因和sarR基因产物，该产物可下调sarA的表达以及由此产生的金黄色葡萄球菌的毒力决定因素。还提供了调节sarA和毒力决定簇表达的方法。本发明的一个优选实施方案提供了与基因产物有关的结构信息，并使得能够鉴定和配制先导化合物以及减少用于治疗和预防I型感染的药物。金黄色葡萄球和相关细菌。 展开▼

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公开/公告号US2005239704A1

专利类型

公开/公告日2005-10-27

原文格式PDF

申请/专利权人 AMBROSE L. CHEUNG;ADHAR MANNA;GONGYI ZHANG;
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申请/专利号US20050063308

发明设计人 AMBROSE L. CHEUNG;ADHAR MANNA;GONGYI ZHANG;
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申请日2005-02-22

分类号A61K38/16;C12Q1/68;C07H21/04;C12N15/74;C12N1/21;C07K14/31;

国家 US

入库时间 2022-08-21 22:23:37

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