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ISOLATED NUCLEIC ACID MOLECULES ENCODING A NOVEL HUMAN SIGNAL TRANSDUCING KINASE-MAPKAP-2; ENCODED PROTEINS, CELLS TRANSFORMED THEREWITH AND USES THEREOF
ISOLATED NUCLEIC ACID MOLECULES ENCODING A NOVEL HUMAN SIGNAL TRANSDUCING KINASE-MAPKAP-2; ENCODED PROTEINS, CELLS TRANSFORMED THEREWITH AND USES THEREOF
Disclosed herein are two newly identified enzymes - mitogen-activated protein kinase-activated protein kinase-2, each comprising a sequence of nucleotides as set forth in SEQ ID NOs: 1 and 3. Each of the herein disclosed enzymes is a serine/threonine signal transduction kinase that is phosphorylated and activated by Erks and p38 MAPK in vitro. Also disclosed, inter alia, are cells containing the recombinant nucleic acid molecules; antisense constructs thereto; antibodies specific for each of the disclosed proteins; methods for using the novel nucleic acid molecules and their gene products including kits containing the same.
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机译:本文公开了两种新近鉴定的酶-促分裂原活化的蛋白激酶活化的蛋白激酶-2,每种酶均包含如SEQ ID NO:1和3所示的核苷酸序列。本文公开的每种酶均为丝氨酸/苏氨酸信号。转导激酶,在体外被Erks和p38 MAPK磷酸化并激活。还特别公开了含有重组核酸分子的细胞。反义构建体;对每种公开的蛋白质具有特异性的抗体;新型核酸分子及其基因产物的使用方法,包括含有该核酸分子的试剂盒。
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