17-(C(CH3) (CH2) O-3C (R4, R5) N (R6, R7))-SUBSTITUTED 19-NOR-PREGNA-1, 3, 5(10)-TRIENE DERIVATIVES AND THEIR MEDICAL USE

摘要

Compounds of formula (I) in which: R1 represents a hydrogen atom or an o-protecting group; R2 represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R3 represents a methyl group having α- or β- configuration; X represents a C¿1-3? alkylene group or a valence bond; Y represents a group of formula -C(R?4) (R5)NR6R7¿ where R?4 and R5¿, which may be the same or different, are each selected from hydrogen atoms, alkyl, alkenyl and alkynyl groups such that the total carbon content of R?4 and R5¿ does not exceed three atoms; R6 represents a hydrogen atom, an aliphatic or araliphatic organic group, or an acyl group comprising an aliphatic, araliphatic or aryl organic group linked to the nitrogen atom by way of a carbonyl group; and R7 is a hydrogen atom or a lower alkyl group; and the dotted line signifies that a double bond may optionally be present at the 16(17)-position exhibit potent cell modulating activity, including antiproliferative and antiangiogenic effects.