INJECTABLE DRUG DELIVERY SYSTEMS WITH CYCLODEXTRIN-POLYMER BASED HYDROGELS

摘要

A cyclodextrin polymer based injectable composition comprising cyclodextrin, a polymer which is capable of forming a hydrogel with the cyclodextrin and a pharmacologically effective amount of at least one drug. The polymer is selected from poly(ethylene glycol), derivatives thereof or a copolymer with a poly(ethylene glycol) segment. The copolymer with a poly(ethylene glycol) segment may include a polymer selected from the group consisting of polyesters, polyurethanes, polyamides, polyethers, polysaccharides, poly (amino acid)s, polypeptides, and proteins. The composition may be injected subcutaneously, intramuscularly, intradermally, or intracranially.